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1

Design, synthesis and antimycobacterial activity of novel ciprofloxacin derivatives

Cilliers, Pieter, Seldon, Ronnett, Smit, Frans J, Aucamp, Janine, Jordaan, Audrey, Warner, Digby F., N'Da, David D.

Journal:

Chemical Biology & Drug Design

Year:

2019

Language:

english

File:

PDF, 1.00 MB

english, 2019

2

Synthesis, Characterization, and Pharmacological Evaluation of Silicon-Containing Aminoquinoline Organometallic Complexes As Antiplasmodial, Antitumor, and Antimycobacterial Agents

Li, Yiqun, de Kock, Carmen, Smith, Peter J., Guzgay, Hajira, Hendricks, Denver T., Naran, Krupa, Mizrahi, Valerie, Warner, Digby F., Chibale, Kelly, Smith, Gregory S.

Journal:

Organometallics

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

3

RiboFACSeq: A new method for investigating metabolic and transport pathways in bacterial cells by combining a riboswitch-based sensor, fluorescence-activated cell sorting and next-generation sequencing

Ghazi, Zohaib, Jahanshahi, Shahrzad, Li, Yingfu, Warner, Digby F.

Journal:

Year:

2017

Language:

english

File:

PDF, 6.18 MB

english, 2017

4

Expanding the anti-TB arsenal

Mizrahi, Valerie, Warner, Digby F.

Journal:

Year:

2019

Language:

english

File:

PDF, 402 KB

english, 2019

5

Making ends meet in mycobacteria

Digby F. Warner, Valerie Mizrahi

Journal:

Molecular Microbiology

Year:

2011

Language:

english

File:

PDF, 75 KB

english, 2011

6

The survival kit of Mycobacterium tuberculosis

Warner, Digby F, Mizrahi, Valerie

Journal:

Nature Medicine

Year:

2007

Language:

english

File:

PDF, 186 KB

english, 2007

7

A derivative of Mycobacterium smegmatis mc2155 that lacks the duplicated chromosomal region

Digby F. Warner, Gilles Etienne, Xiao-Ming Wang, Limenako G. Matsoso, Stephanie S. Dawes, Karine Soetaert, Neil G. Stoker, Jean Content, Valerie Mizrahi

Journal:

Year:

2006

Language:

english

File:

PDF, 226 KB

english, 2006

8

IS1096-mediated DNA rearrangements play a key role in genome evolution of Mycobacterium smegmatis

Xiao-Ming Wang, Alexandra Galamba, Digby F. Warner, Karine Soetaert, Jane S. Merkel, Michael Kalai, Pablo Bifani, Philippe Lefèvre, Valerie Mizrahi, Jean Content

Journal:

Year:

2008

Language:

english

File:

PDF, 1.13 MB

english, 2008

9

Synthesis and Antiplasmodial and Antimycobacterial Evaluation of New Nitroimidazole and Nitroimidazooxazine Derivatives

Tukulula, Matshawandile, Sharma, Rajni-Kant, Meurillon, Maïa, Mahajan, Aman, Naran, Krupa, Warner, Digby, Huang, Jianxing, Mekonnen, Belew, Chibale, Kelly

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 417 KB

english, 2013

10

The role of DNA repair in M. tuberculosis pathogenesis

Digby F. Warner

Journal:

Drug Discovery Today: Disease Mechanisms

Year:

2010

Language:

english

File:

PDF, 178 KB

english, 2010

11

Mycobacterial genetics in target validation

Digby F. Warner, Valerie Mizrahi

Journal:

Drug Discovery Today: Technologies

Year:

2004

Language:

english

File:

PDF, 119 KB

english, 2004

12

Complex genetics of drug resistance in Mycobacterium tuberculosis

Warner, Digby F, Mizrahi, Valerie

Journal:

Nature Genetics

Year:

2013

Language:

english

File:

PDF, 237 KB

english, 2013

13

Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents

Mjambili, Faith, Njoroge, Mathew, Naran, Krupa, De Kock, Carmen, Smith, Peter J., Mizrahi, Valerie, Warner, Digby, Chibale, Kelly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 360 KB

english, 2014

14

Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacterium tuberculosis

Hoffman, Amanda E., DeStefano, Michelle, Shoen, Carolyn, Gopinath, Krishnamoorthy, Warner, Digby F., Cynamon, Michael, Doyle, Robert P.

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 585 KB

english, 2013

15

Vitamin B 12 metabolism in Mycobacterium tuberculosis

Gopinath, Krishnamoorthy, Moosa, Atica, Mizrahi, Valerie, Warner, Digby F

Journal:

Future Microbiology

Year:

2013

Language:

english

File:

PDF, 869 KB

english, 2013

16

Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery

Kigondu, Elizabeth M., Wasuna, Antonina, Warner, Digby F., Chibale, Kelly

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 585 KB

english, 2014

17

Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolites

Kigondu, Elizabeth M., Njoroge, Mathew, Singh, Kawaljit, Njuguna, Nicholas, Warner, Digby F., Chibale, Kelly

Journal:

Year:

2014

Language:

english

File:

PDF, 253 KB

english, 2014

18

Diversity and disease pathogenesis in Mycobacterium tuberculosis

Warner, Digby F., Koch, Anastasia, Mizrahi, Valerie

Journal:

Trends in Microbiology

Year:

2015

Language:

english

File:

PDF, 568 KB

english, 2015

19

The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?

Koch, Anastasia, Mizrahi, Valerie, Warner, Digby F

Journal:

Emerging Microbes & Infections

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

20

Shortening Treatment for Tuberculosis — Back to Basics

Warner, Digby F., Mizrahi, Valerie

Journal:

New England Journal of Medicine

Year:

2014

Language:

english

File:

PDF, 366 KB

english, 2014

21

The Complex Mechanism of Antimycobacterial Action of 5-Fluorouracil

Singh, Vinayak, Brecik, Miroslav, Mukherjee, Raju, Evans, Joanna C., Svetlíková, Zuzana, Blaško, Jaroslav, Surade, Sachin, Blackburn, Jonathan, Warner, Digby F., Mikušová, Katarína, Mizrahi, Valerie

Journal:

Chemistry & Biology

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

22

Translating genomics research into control of tuberculosis: lessons learned and future prospects

Warner, Digby F, Mizrahi, Valerie

Journal:

Year:

2014

Language:

english

File:

PDF, 376 KB

english, 2014

23

Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization

Candice, Soares de Melo, Feng, Tzu-Shean, van der Westhuyzen, Renier, Gessner, Richard K., Street, Leslie J., Morgans, Garreth L., Warner, Digby F., Moosa, Atica, Naran, Krupa, Lawrence, Nina, Boshoff

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 7.48 MB

english, 2015

24

Corrigendum to “Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization” [Bioorg. Med. Chem. 23 (2015) 7240–7250]

Soares de Melo, Candice, Feng, Tzu-Shean, van der Westhuyzen, Renier, Gessner, Richard K., Street, Leslie J., Morgans, Garreth L., Warner, Digby F., Moosa, Atica, Naran, Krupa, Lawrence, Nina, Boshoff

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 178 KB

english, 2016

25

Essential roles for imuA' - and imuB -encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis

Digby F. Warner, Duduzile E. Ndwandwe, Garth L. Abrahams, Bavesh D. Kana, Edith E. Machowski, Česlovas Venclovas, Valerie Mizrahi and Stephen J. Benkovic

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.40 MB

english, 2010

26

Synthesis, characterization and antimicrobial evaluation of mono- and polynuclear ferrocenyl-derived amino and imino complexes

Baartzes, Nadia, Stringer, Tameryn, Seldon, Ronnett, Warner, Digby F., de Kock, Carmen, Smith, Peter J., Smith, Gregory S.

Journal:

Journal of Organometallic Chemistry

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

27

Sa1972 Factors Influencing Infliximab and Adalimumab Antibody Formation and 6 Month Retrospective Follow up in a Tertiary IBD Centre

Johnston, Emma L., Warner, Ben D., Digby-Bell, Jonathan L., Arkir, Zehra, Unsworth, Nick, Anderson, Simon H., Sanderson, Jeremy D., Irving, Peter M.

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 905 KB

english, 2016

28

ChemInform Abstract: Synthesis of New Verapamil Analogues and Their Evaluation in Combination with Rifampicin Against Mycobacterium tuberculosis and Molecular Docking Studies in the Binding Site of Efflux Protein Rv1258c

Singh, Kawaljit, Kumar, Malkeet, Pavadai, Elumalai, Naran, Krupa, Warner, Digby F., Ruminski, Peter G., Chibale, Kelly

Journal:

Year:

2014

File:

PDF, 12 KB

2014

29

Mono- and polynuclear ferrocenylthiosemicarbazones: Synthesis, characterisation and antimicrobial evaluation

Baartzes, Nadia, Stringer, Tameryn, Okombo, John, Seldon, Ronnett, Warner, Digby F., de Kock, Carmen, Smith, Peter J., Smith, Gregory S.

Journal:

Journal of Organometallic Chemistry

Year:

2016

Language:

english

File:

PDF, 348 KB

english, 2016

30

Design, Synthesis and Evaluation of Novel Hybrid Efflux Pump Inhibitors for use against Mycobacterium tuberculosis

Kumar, Malkeet, Singh, Kawaljit, Naran, Krupa, Hamzabegovic, Fahreta, Hoft, Daniel F, Warner, Digby F., Ruminski, Peter, Abate, Getahun, Chibale, Kelly

Journal:

ACS Infectious Diseases

Year:

2016

Language:

english

File:

PDF, 1010 KB

english, 2016

31

Bioluminescent reporters for rapid mechanism of action assessment in tuberculosis drug discovery

Naran, Krupa, Moosa, Atica, Barry, Clifton E., Boshoff, Helena I. M., Mizrahi, Valerie, Warner, Digby F.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

32

Nucleotide Metabolism and DNA Replication

Warner, Digby F., Evans, Joanna C., Mizrahi, Valerie

Journal:

Microbiology Spectrum

Year:

2014

Language:

english

File:

PDF, 409 KB

english, 2014

33

Utilisation of anti-TNF levels in a UK tertiary IBD centre

Johnston, E L, Warner, B D, Digby-Bell, J L, Unsworth, N, Anderson, S, Sanderson, J D, Arkir, Z, Irving, P M

Journal:

Frontline Gastroenterology

Year:

2016

Language:

english

File:

PDF, 719 KB

english, 2016

34

[ACM Press the Annual Conference of the South African Institute of Computer Scientists and Information Technologists - Johannesburg, South Africa (2016.09.26-2016.09.28)] Proceedings of the Annual Conference of the South African Institute of Computer Scientists and Information Technologists on - SAICSIT '16 - Effective Visualization of Tuberculosis Three-Drug Assays

Silubonde, Sunganani, Warner, Digby, Kuttel, Michelle

Year:

2016

Language:

english

File:

PDF, 1.30 MB

english, 2016

35

DNA Replication in Mycobacterium tuberculosis

Warner, Digby F., Lamers, Meindert H., Ditse, Zanele

Journal:

Microbiology Spectrum

Year:

2017

Language:

english

File:

PDF, 1.94 MB

english, 2017

36

The Influence of HIV on the Evolution of Mycobacterium tuberculosis

Koch, Anastasia S., Brites, Daniela, Stucki, David, Evans, Joanna C., Seldon, Ronnett, Heekes, Alexa, Mulder, Nicola, Nicol, Mark, Oni, Tolu, Mizrahi, Valerie, Warner, Digby F., Parkhill, Julian, Gagn

Journal:

Molecular Biology and Evolution

Year:

2017

Language:

english

File:

PDF, 21.80 MB

english, 2017

37

Vedolizumab: early experience and medium-term outcomes from two UK tertiary IBD centres

Samaan, Mark A, Pavlidis, Polychronis, Johnston, Emma, Warner, Ben, Digby-Bell, Jonathan, Koumoutsos, Ioannis, Fong, Steven, Goldberg, Rimma, Patel, Kamal, Gulati, Shraddha, Medcalf, Lucy, Sastrillo,

Journal:

Frontline Gastroenterology

Year:

2016

Language:

english

File:

PDF, 441 KB

english, 2016

38

Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes

Stringer, Tameryn, Seldon, Ronnett, Liu, Nicole, Warner, Digby F., Tam, Christina, Cheng, Luisa W., Land, Kirkwood M., Smith, Peter J., Chibale, Kelly, Smith, Gregory S.

Journal:

Dalton Transactions

Year:

2017

Language:

english

File:

PDF, 1.37 MB

english, 2017

39

Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c

Moosa, Atica, Lamprecht, Dirk A., Arora, Kriti, Barry, Clifton E., Boshoff, Helena I. M., Ioerger, Thomas R., Steyn, Adrie J. C., Mizrahi, Valerie, Warner, Digby F.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 1011 KB

english, 2017

40

PTH-053 Factors Influencing Infliximab and Adalimumab Antibody Formation and 6 Month Retrospective Follow-Up in A Tertiary IBD Centre

Warner, BD, Johnston, E, Digby-Bell, J, Arkir, Z, Unsworth, N, Anderson, S, Sanderson, J, Irving, P

Journal:

Year:

2016

Language:

english

File:

PDF, 57 KB

english, 2016

41

Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagar™STEC media

Kalule, John Bosco, Fortuin, Suereta, Calder, Bridget, Robberts, Lourens, Keddy, Karen H., Nel, Andrew, Garnett, Shaun, Nicol, Mark, Warner, Digby F., Soares, Nelson C., Blackburn, Jonathan M.

Journal:

Journal of Proteomics

Year:

2017

Language:

english

File:

PDF, 1.64 MB

english, 2017

42

Novel Anti-tubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure Activity Relationship and Target Identification Studies

Wilson, Colin R., Gessner, Richard K., Moosa, Atica, Seldon, Ronnett, Warner, Digby F., Mizrahi, Valerie, Soares de Melo, Candice, Simelane, Sandile B., Nchinda, Aloysius T, Abay, Efrem, Taylor, Dale,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.20 MB

english, 2017

43

PTU-062 Vedolizumab: Early Experience and Medium-Term Follow up Data from Two UK Tertiary IBD Centres

Samaan, MA, Pavlidis, P, Johnston, E, Warner, B, Digby-Bell, J, Koumoutsos, I, Fong, S, Goldberg, R, Gulati, S, Medcalf, L, Sastrillo, M, Bedwell, T, Brown-Clarke, C, Bidwell-Sullivan, J, Forsyth, K,

Journal:

Year:

2016

Language:

english

File:

PDF, 163 KB

english, 2016

44

PTU-075 Utility of measuring adalimumab drug levels and anti-drug antibodies in clinical practice: a large IBD referral centre experience

Warner, BD, Johnston, EL, Digby-Bell, JL, Unsworth, N, Anderson, S, Sanderson, JD, Arkir, Z, Irving, PM

Journal:

Year:

2015

Language:

english

File:

PDF, 72 KB

english, 2015

45

PWE-038 Utility of measuring infliximab drug levels and anti-drug antibodies in clinical practice: a large ibd referral centre experience

Johnston, EL, Warner, BD, Digby-Bell, JL, Unsworth, N, Anderson, S, Sanderson, JD, Arkir, Z, Irving, PM

Journal:

Year:

2015

Language:

english

File:

PDF, 73 KB

english, 2015

46

Key Amino Acids in the Bacterial (6-4) Photolyase PhrB from Agrobacterium fabrum

Graf, Dominik, Wesslowski, Janine, Ma, Hongju, Scheerer, Patrick, Krauß, Norbert, Oberpichler, Inga, Zhang, Fan, Lamparter, Tilman, Warner, Digby F.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.12 MB

english, 2015

47

Activity of Colistin in Combination with Meropenem, Tigecycline, Fosfomycin, Fusidic Acid, Rifampin or Sulbactam against Extensively Drug-Resistant Acinetobacter baumannii in a Murine Thigh-Infection Model

Fan, Bing, Guan, Jie, Wang, Xiumei, Cong, Yulong, Warner, Digby F.

Journal:

Year:

2016

Language:

english

File:

PDF, 793 KB

english, 2016

48

Contribution of increased mutagenesis to the evolution of pollutants-degrading indigenous bacteria

Ilmjärv, Tanel, Naanuri, Eve, Kivisaar, Maia, Warner, Digby F.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.90 MB

english, 2017

49

Drug permeation and metabolism in Mycobacterium tuberculosis : Prioritising local exposure as essential criterion in new TB drug development

Tanner, Lloyd, Denti, Paolo, Wiesner, Lubbe, Warner, Digby F.

Journal:

Year:

2018

Language:

english

File:

PDF, 782 KB

english, 2018

50

Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents

Kapp, Erika, Visser, Hanri, Sampson, Samantha, Malan, Sarel, Streicher, Elizabeth, Foka, Germaine, Warner, Digby, Omoruyi, Sylvester, Enogieru, Adaze, Ekpo, Okobi, Zindo, Frank, Joubert, Jacques

Journal:

Year:

2017

Language:

english

File:

PDF, 2.67 MB

english, 2017

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